Over the past decade, Zimbabwe has made great strides towards reducing new HIV infections among the general population – a 70% reduction between 2010 and 2021, according to UNAIDS estimates.
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Welcome to the last differentiated service delivery (DSD) newsletter of 2022 from IAS – the International AIDS Society. In this edition, we focus on DSD for PrEP with insights from Zimbabwe and Zambia.

Long-acting injectable PrEP will support DSD for HIV prevention in Zimbabwe

Joseph Murungu, Senior Technical Advisor, Pangaea Zimbabwe AIDS Trust, Zimbabwe, writes:

Over the past decade, Zimbabwe has made great strides towards reducing new HIV infections among the general population – a 70% reduction between 2010 and 2021, according to UNAIDS estimates. Despite this significant progress, the number of new HIV infections per year is still unacceptably high as the country missed the 2020 target of a 90% reduction in new infections. It is now important to ensure that HIV prevention programmes reach previously underserved groups who may benefit the most from combination HIV prevention interventions, including pre-exposure prophylaxis (PrEP).

In its latest PrEP implementation guidance brief, the World Health Organization (WHO) recommends differentiated, simplified, de-medicalized and comprehensive PrEP services. DSD, as outlined in this country policy development brief, simplifies PrEP by providing easier-to-collect, longer PrEP refills at more convenient locations. It reduces the clinical package at certain types of visits, enabling lay cadres to manage such visits and increasing utilization of virtual platforms, and supports service integration. The brief also recommends that people using PrEP should be assessed for suitability and have the option to choose a less intensive differentiated PrEP service delivery model as soon as it is feasible.

In October 2022, Zimbabwe demonstrated its commitment to further reducing new HIV infections when the national Medicines Control Authority approved CAB-LA for HIV prevention. DSD for prevention, including differentiated PrEP delivery, is part of the Operational and Service Delivery Manual for the Prevention, Care and Treatment of HIV in Zimbabwe (OSDM) updated in 2022.

Large-scale access to different PrEP options, including CAB-LA, however, will only be possible if the price of CAB-LA is substantially reduced. In addition, we need to address issues around availability, health system preparedness, human resources, client/people-centred service delivery platforms, supply chains and monitoring effective use, as well as creating a stigma-free, friendly environment. 

We have exciting new HIV prevention methods available – now let’s make them affordable and accessible to ensure that people can access the PrEP option that works best for them.

Read the full piece

 

DSD in action: Improving key populations’ access to HIV testing and prevention services in Zambia

“In Zambia, the social network testing strategy has been an effective way to influence uptake of health services among hard-to-reach key populations.”

We spoke with Linah Kampilimba Mwango, Technical Director at Ciheb Zambia and Deputy Chief of Party for the Community Impact to Reach Key and Underserved Individuals for Treatment and Support (CIRKUITS) project, and Henry M Sakala, Key Population Technical Lead on the CIRKUITS project.

What are some of the challenges faced by key populations and HIV testing and prevention in Zambia?

Sex work and same-sex sexual relations are criminalized in Zambia. Punitive laws and law enforcement practices make it more difficult for HIV programmes to reach sex workers, men who have sex with men and transgender people. Hostile environments and stigma, even from healthcare providers, limit key populations’ access to HIV services due to fear of arrest, detention and discrimination.

There is an inadequate offering of key population-friendly services in the country and only a limited number of healthcare providers are trained in key population sensitivity, safety and security.

How does social network testing address the challenges faced by key populations in accessing HIV testing and prevention services in Zambia?

The social network strategy is based on the theory that people in the same social and sexual networks have similar risk behaviours. It involves identifying “recruiters”, who include: (1) people living with HIV; and (2) people vulnerable to acquiring HIV. Recruiters must also be willing to recruit “network members”, or members of their social or sexual networks, for HIV testing and prevention services.

Once network members are recruited and receive an HIV test, they are given the opportunity to become recruiters for their own networks. The process of enrolling key populations to test and recruit their social and/or sexual network members continues, producing successive waves of recruitment that can extend into hidden networks and to hard-to-reach clients. Recruitment and testing of network members are encouraged and sustained through small monetary or non-monetary incentives.

Read the full interview

 

Don't miss

Community-led monitoring guide to support inclusion of CLM in funding requests to the Global Fund

This guide, developed by IAS in collaboration with partners, is intended to support the inclusion of community-led monitoring (CLM) in funding requests to the Global Fund.

 

Looking ahead, looking back

Looking ahead …

  • 30 November – 13 January: Submit a draft abstract to the IAS Abstract Mentor Programme for IAS 2023, the 12th IAS Conference on HIV Science. If you are new to writing scientific abstracts, our expert mentors can provide advice and feedback on how to develop successful abstracts and increase your chances of presenting at IAS 2023 taking place in Brisbane, Australia, and virtually from 23 to 26 July 2023.
  • 1 December: Listen to our special World AIDS Day episode of HIV unmuted, the IAS podcast, on why we must put people first to address the persisting inequalities in the HIV response. The guests joining our host, Femi Oke, include Yvette Raphael, Executive Director of Advocates for the Prevention of HIV in Africa; Peter Sands, Executive Director of the Global Fund to fight AIDS, Tuberculosis and Malaria; and the IAS Me and My Healthcare Provider awardees.
  • 6-9 December: ICAP at Columbia’s HIV Coverage, Quality and Impact Network (CQUIN) will convene its sixth annual meeting in Durban, South Africa. The meeting will focus on “DSD 2.0: The Future of Differentiated Service Delivery”.
     

Looking back …

  • View the recording of the fifth meeting of the South African Measurement and Surveillance of HIV Epidemics (MeSH) team on differentiated service delivery and aims to foster further collaboration and strengthening of routine HIV information systems in South Africa. 
  • View the recording of the webinar “Strategic information to support and scale up people-centred differentiated HIV service delivery" organized by UNAIDS and partners.

 

What we're reading

Providing differentiated service delivery to the ageing population of people living with HIV, Godfrey C et al, JIAS, September 2022

 

This commentary proposes that older individuals living with HIV, especially those with co-morbidities, may benefit from a DSD approach that adapts care to the specific challenges of ageing with HIV. The authors recommend the development of related educational materials, health worker capacity building and outreach designed specifically to support this age group.

The effectiveness, feasibility and acceptability of HIV service delivery at private pharmacies in sub‐Saharan Africa: a scoping review, Kuo AP et al, JIAS, October 2022

This review analysed effectiveness and implementation outcomes of the delivery of HIV testing, antiretroviral therapy (ART) and/or PrEP at private pharmacies in sub-Saharan Africa. The authors conclude that pharmacy-delivered HIV services may be feasible to implement and acceptable to clients and providers in parts of sub-Saharan Africa, with limited evidence available from outside East Africa.

Acceptability and feasibility of leveraging community-based HIV counselling and testing platforms for same-day oral PrEP initiation among adolescent girls and young women in Eastern Cape, South Africa, Medina-Marino A et al, JIAS, July 2022

Analysing data from a randomized controlled trial of a behavioural intervention - the Community PrEP Study (CPS) – this research article shows that leveraging community-based HIV testing services platforms to provide same-day PrEP initiation and refill services was acceptable to adolescent girls and young women in South Africa.

Examining the Use of HIV Self-Testing to Support PrEP Delivery: a Systematic Literature Review, Kiptinness C et al, Curr HIV/AIDS Rep, July 2022

This systematic literature review found that HIV self-testing (HIVST) to support PrEP delivery was acceptable, feasible and preferred. HIVST use for PrEP continuation largely resulted in similar outcomes to standard-of-care delivery and was perceived acceptable and feasible.

For more on HIVST and PrEP, see the World Health Organization’s 2022 technical brief, “Differentiated and simplified pre-exposure prophylaxis for HIV prevention”.

Efficiency of 6-month PrEP dispensing with HIV self-testing in Kenya: an open-label, randomised, non-inferiority, implementation trial, Ngure K et al, Lancet HIV, July 2022

This randomized, open-label, non-inferiority trial from Kenya demonstrated that six-month PrEP dispensing with HIVST for interim testing reduced the number of PrEP clinic visits in half without compromising HIV testing, retention, or adherence.

Fee for home delivery and monitoring of antiretroviral therapy for HIV infection compared with standard clinic-based services in South Africa: a randomised controlled trial, Barnabas RV et al, Lancet HIV, November 2022

This research article describes outcomes from a randomized control trial - the Deliver Health Study - of a fee for home delivery of ART compared with free clinic ART delivery in South Africa. The authors found that a fee for home delivery and monitoring of ART significantly increased viral suppression compared with clinic-based ART.

Improved virologic outcomes in postpartum women living with HIV referred to differentiated models of care: A randomised controlled trial, Myer L et al, AIDS, September 2022

This randomized controlled trial compared immediate postpartum referral of women living with HIV who initiated ART in pregnancy to either an adherence club (the intervention), or a local primary health care clinic (the standard of care, control) in South Africa. The authors found that early DSD referral was associated with reduced viraemia through 24 months postpartum and may be an important strategy to improve maternal virologic outcomes.

 

What we're watching

Sha’p Left Primary Health Care Club in South Africa

Watch this video about a community-based model to support people to access their chronic care medication refills.

 

Get in touch

Do you have content for the next newsletter? We want to hear from you. Email us at dsd@iasociety.org.


www.differentiatedservicedelivery.org

 

Photo credits in order of appearance: 
(1) MSF/Ikram N’gadi, (2) Ciheb Zambia, (3) Cipla Foundation South Africa

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