Welcome to the final differentiated service delivery (DSD) newsletter of 2024 from IAS – the International AIDS Society.
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Welcome to the final differentiated service delivery (DSD) newsletter of 2024 from IAS – the International AIDS Society. In this edition, we focus on differentiated delivery of pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), highlighting recently revised guidance from the World Health Organization.

Putting PEP into the HIV prevention foreground: The revised WHO PEP guidelines

By Kerry Mangold and Ayesha Ismail, Genesis Analytics, South Africa

For far too long, PEP in African countries has been associated solely with occupational HIV exposure and survivors of sexual violence. The untapped potential of PEP in curbing new HIV acquisitions remains a critical concern, especially considering the 1.3 million new acquisitions in 2022, a figure well above the global target.

However, a promising shift is underway as national ministries of health echo calls for the “rejuvenation”, “nurturing” and “revitalization” of PEP in Kenya, South Africa and Zimbabwe, respectively.

We are at a pivotal moment, channelling this collective energy to effectively implement the World Health Organization’s (WHO’s) recently revised PEP guidelines, which recommend community delivery and task sharing, ultimately aiming to get PEP closer to the people who need it.

Innovative delivery models and a swift alignment of supportive policies will be essential to make PEP more accessible; these models include online delivery, vending machines, pharmacy access and use of mobile clinics and drop-in centres with strong linkages and referrals. Moreover, integrating PEP into the broader prevention landscape, including the services offered to key and vulnerable populations, is crucial.

As countries embark on reimagining HIV prevention strategies and capitalize on the current momentum spurred by the updated PEP guidelines, there is a pressing need to advocate for and prioritize PEP as a pivotal component of HIV prevention efforts.

Through collaborative efforts, like the South-to-South HIV Prevention Learning Network (SSLN) and its i2i (insight to implementation) stream, we are documenting valuable insights and best practices on effective delivery, showcasing the translation of global directives into community-focused solutions. This collaborative platform supports countries to swiftly document, share and adapt their programmes based on regional learnings and best practices, paving the way for a more robust HIV prevention response, placing PEP in the foreground as part of the Choice agenda.

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DSD in action

Overcoming access barriers to HIV prevention commodities in São Paulo, Brazil 

By Maria Cristina Abbate, STD/AIDS Coordination Office of São Paulo, Brazil

Promoting access to HIV services for populations disproportionately affected by the HIV epidemic is a global challenge that requires reaching beyond the confines of health units. To address this, the STD/AIDS Coordination Office of São Paulo has implemented initiatives that integrate HIV prevention into daily life. 

The Coordination Office has provided internal and external condoms in over 90 bus terminals and stations across the city, a compact health unit within a subway station, and the “PrEP on the Street” project, which brings services to open high-traffic areas. In addition, it has installed automated dispensing machines for PrEP, PEP and HIV self-tests at two subway stations serving more than 180,000 passengers daily. 

This effort has significantly expanded access to prevention via the SPrEP – PrEP and PEP Online platform, which offers teleconsultations every day (including holidays and weekends) through a free app provided by the Municipal Health Department. Through this online service, users receive their prescriptions and a QR code for access to the prophylactics at the machines. 

In the first five months of operation, these machines registered over 1,000 distributions, showing a continuous increase in access for all users. Among women, for instance, there has been an increase in PEP access, indicating a demand for this preventive method and demonstrating the viability of meeting this demand by expanding the availability of prophylactics. 

Read the full piece

 

Don't miss

Access resources from the IAS-WHO multi-country workshop on differentiation at re-engagement in HIV care, held in Johannesburg, South Africa, from 12 to 14 November. The objective of the workshop was to support country teams to discuss and design context-specific re-engagement pathways to support their HIV treatment programmes.

 

Looking ahead, looking back

Looking ahead …

  • From 9 to 13 December, the CQUIN country network of ICAP at Columbia University will convene all 21 network countries for its 8th annual meeting in Johannesburg, South Africa. The meeting objectives include sharing implementation progress, performance updates, innovations, impact and challenges of person-centred service delivery.
  • Submit your abstract and book a satellite at IAS 2025, the 13th IAS Conference on HIV Science. It will take place in Kigali, Rwanda, from 13 to 17 July 2025, with pre-conferences on 13 July. Abstract submission closes on 22 January and satellite submissions remain open until 13 March.
  • If you are an active researcher, you can register to attend the 32nd Conference on Retroviruses and Opportunistic Infections (CROI), held from 9 to 12 March 2025 in San Francisco, United States. Read more about CROI’s preliminary programme.
  • In March 2024, the US Congress granted the US President’s Emergency Plan for AIDS Relief (PEPFAR) a one-year reauthorization (until 25 March 2025). PEPFAR is currently working on a five-year reauthorization to enable its partner countries to conduct long-term planning to achieve sustainable control of the HIV pandemic. For more information: Journal of the International AIDS Society viewpoint, Health Policy Watch article, Brookings commentary.

Looking back …

  • Access the recording of the webinar, “From UHC2030 to Sustained HIV Services: How Strengthened Primary Health Care Systems Can Get Us There”, co-hosted by PATH and WHO.
  • Access the recording of the webinar, “Online pharmacy PrEP and PEP: Evidence, learnings and recommendations from Kenya”, hosted by PATH with key partners involved in the pilot project.

 

What we're reading

Feasibility and Impact of Community Pharmacy and Novel Pick-Up Points for Antiretroviral Therapy Pre-exposure Prophylaxis Initiation and Continuation in Low and Middle-income Countries, Lalla-Edward ST, Venter WDF, Curr HIV/AIDS Rep, Nov 2024

This literature review explores recent developments in community access to PrEP for HIV prevention in low- and middle-income countries. While community pharmacies and novel pick-up points offer promising avenues to expand access, operational complexities and regulatory frameworks present significant challenges. The authors conclude that addressing policy gaps, strengthening pharmacist training, and promoting client-centred approaches are essential for scaling up access to PrEP in low- and middle-income countries.

Factors influencing the implementation of a guideline for re-engagement in HIV care in primary care settings in Johannesburg, South Africa: A qualitative study, Makina-Zimalirana N et al, PLOS Glob Public Health, Oct 2024

The aim of this qualitative cross-sectional study was to understand the barriers and facilitators influencing the adoption and scalability of strategies for re-engagement in HIV care. This was done through the assessment of healthcare providers’ perspectives on the implementation of re-engagement initiatives across nine primary care facilities. While tools like job aides were seen as helpful for standardizing care, staff shortages, duplicated documentation and the need for ongoing training posed challenges to seamless adoption and effectiveness.

Preferences for Delivery of HIV Prevention Services Among Healthcare Users in South Africa: A Discrete Choice Experiment, Martin CE et al, AIDS Behav, Oct 2024

Through a discrete choice experiment, this study explored preferences for components of a PrEP service delivery package among clients accessing primary healthcare services. PrEP initiation at a pharmacy or mobile clinic was valued equally to initiating PrEP at a clinic. There was a preference for six-monthly over three-monthly follow-up. Participants preferred collecting PrEP from a pharmacy, through home delivery and from a vending machine and preferred HIV self-testing over healthcare provider testing. The authors conclude that there is a need to expand decentralized and self-led HIV prevention services.

A Qualitative Assessment of South Africa’s Central Chronic Medication Dispensing and Distribution Program for Differentiated Antiretroviral Therapy Delivery in Umlazi Township, South Africa: Client Perspectives after 12 Months of Participation, Mendoza-Graf A et al, AIDS Behav, Nov 2024

This qualitative study evaluated the implementation of South Africa’s Central Chronic Medicine Dispensing and Distribution (CCMDD) programme in one district. Results indicated consistently positive views of CCMDD among clients and providers, primarily attributed to convenient and smooth medication pick-up. Community HIV stigma was a persistent challenge, as was nurses’ judgmental communication style. To ensure CCMDD’s success, continued focus is needed on decreasing HIV stigma beyond the clinic context and improving provider-client relationships.

Letter to the Editor: “Cost-effectiveness and budget impact analysis of the implementation of differentiated service delivery models for HIV treatment in Mozambique: a modelling study”: Resource reductions are not equal to cost savings, Rosen S et al, J Int AIDS Soc, Oct 2024

In their letter to the editor, the authors comment on the research article, “Cost-Effectiveness and Budget Impact Analysis of the Implementation of Differentiated Service Delivery Models for HIV Treatment in Mozambique: a Modelling Study”, by Uetela et al. They congratulate the research team on their efforts to conduct this complex modelling study while raising concern that the results could be misread as DSD models saving money for the health system. While the study seems to report significant “savings”, these are not to be understood as actual monetary or budgetary savings but as opportunity costs, primarily from reduced healthcare provider time.

Response: “Cost-effectiveness and budget impact analysis of the implementation of differentiated service delivery models for HIV treatment in Mozambique: a modelling study”: resource reductions are not equal to cost savings, Moiana Uetela D, J Int AIDS Soc, Oct 2024

In their response, the authors of the original research acknowledge the points raised by Rosen et al, clarifying that the “savings” represent the potential for reallocated provider time to improve care for other clients or health areas, rather than direct financial savings.

Updated guidelines on HIV post-exposure prophylaxis: continued efforts towards increased accessibility, Allan-Blitz LT, Mayer KH, J Int AIDS Soc, 2024 Nov


PEP remains an underutilized HIV prevention tool. This commentary highlights the importance of the 2024 WHO PEP guidelines for increasing access to PEP. The guidelines strongly recommend that: (1) PEP be delivered in community settings (for example, pharmacies, police stations and online platforms); and (2) PEP delivery and monitoring be done via task sharing involving non-specialist health workers. To support implementation, the authors recommend training of the workforce and the development of detailed templates addressing heterogeneity of community settings and of the populations among whom PEP may be needed.

 

What we're watching

Demand for six-monthly ARV supplies in South Africa

Watch this video accompanying the Treatment Action Campaign’s march to deliver a memorandum to South African government officials demanding that eligible people living with HIV urgently start receiving a six-month supply of antiretrovirals (ARVs). Deputy President Paul Mashatile has since confirmed the government’s decision to provide six-monthly ARV supplies.

 

Get in touch

Do you have content for the next newsletter? We want to hear from you.
Email us at dsd@iasociety.org.

differentiatedservicedelivery.org

 

Photo credits in order of appearance: 
(1)
Peter Casaer (courtesy of MSF), (2) STD/AIDS Coordination Office of São Paulo, Brazil (3) IAS (4) Newzroom Afrika

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